Chronic pain treatment

Proteins must function properly in the cell at the right time in the right place. Because of its complex dendritic structure and its function, this is more important in neurons than in other cells. Researchers at Thomas Jefferson University have now discovered that phosphorylation is a common type of protein modification that works in a novel way that alters the location of proteins that are critical to neuronal function and pathological pain. They found that phosphorylation could occur outside neurons and affect protein function, localization and pain.

Published on July 18 in PLOS Biology, the study provided a potential new goal of developing alternatives to existing painkilling medications.

The corresponding author, Dr Matthew Dalva, said that although we have not yet discovered the exact mechanism that led to such a modification, this finding offers the goal of developing new therapies and a powerful new tool for learning synapses in general.

Unlike pain caused by the effects of inflammation, the pathological pain usually comes from neuronal dysfunction, pain can be felt even without underlying cause or continue to be painful after a long period of time from the start of the event, such as migraine or chronic pain.

Researchers have shown that NMDA receptors in neurons play an important role in pathological pain but are also important in many other neurological processes such as memory and learning, making them an undesirable target of direct drug suppression.

In a series of studies, by Hospitalkhoj and the University of Texas at Dallas showed that the second receptor, ephrin B, is phosphorylated outside of neurons in response to pain. This extracellular protein modification allows the ephrin B receptor EphB2 to adhere to the NMDA receptor. This interaction then moves NMDA receptors into synaptic spaces and alters NMDA receptor function, resulting in increased pain sensitivity.

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The researchers also showed that chemicals that block the pain by blocking the interaction between EphB2 and NMDA receptors. The opposite is true. By artificially promoting the interaction between these two receptors, the neurons become hypersensitive to the pain so that touching alone can cause painful reactions or allodynia.

Dr. Dalva said: "It offers us an easier goal of drug development because protein modifications that cause neurological sensitivity to pain occur extracellularly." This is a promising step forward in pain management.

Menstruation and Premenstrual Syndrome (PMS)

Menstrual or menstrual means that women regularly bleed, usually once a month for 3-7 days. Premenstrual syndrome is used to describe the irritability and unpleasant symptoms that women may experience a few days before menstruation.

What to know about menstruation

Menstrual pain

Women sometimes experience pain symptoms during menstruation, and most women experience "menstrual pain" almost always. Some women experience severe menstrual pain (called dysmenorrhea) and may experience severe discomfort for a few days each menstrual cycle.

You can use over-the-counter painkillers to relieve menstrual pain, but it is best to see a doctor if you have a bad menstrual cramp.

Menorrhagia

Some women have excessive menstrual flow. This is called menorrhagia, which is defined as excessive bleeding, bleeding longer. Most women shed about 6-8 teaspoons of blood during menstruation, but this is almost impossible to measure. If you find yourself needing to change sanitary napkins or napkins very frequently (as recommended by the manufacturer) and see large blood clots, your menstrual flow may be abnormally high.

Menorrhagia can be caused by many factors, including hormonal imbalances, IUDs, or uterine fibroids; for many women, the cause is unknown.

Menstrual period is not necessarily accompanied by dysmenorrhea. However, if you are unlucky enough to experience menorrhagia, severe dysmenorrhea, or irregular menstruation every few days, you will need to see a doctor and consult on how to treat dysmenorrhea and menorrhagia.

If you continue to experience menorrhagia, it is advisable to see a doctor to ensure there is no anemia (anemia and iron deficiency may cause you to feel tired and dizzy).

According to your reasons for menorrhagia, there are many treatments. If caused by hormone imbalance, you can follow the doctor's advice to use a variety of drugs to treat hormone imbalance, for other reasons, there are alternative treatment options.

Menstruation did not come

Some women's menstruation has been very regular for many years, but may not come suddenly for some time. If so, first of all, pregnancy tests should be done at home to rule out pregnancy.

If the menstruation did not come more than 6 months, this is medically called "amenorrhea." There are many reasons why menstruation may suddenly stop, including rapid weight gain and loss, over-exercise and over-stress. If you find yourself having hot flashes and decreased libido, you may be the initial symptom of menopause (menopause).

No matter what your symptoms are, you should seek medical attention if there is a regular menstrual change or stop.

What is PMS?

What is PMS?

Premenstrual syndrome (PMS), also known as premenstrual tension (PMT), is used to describe the many symptoms that many women experience in the second half of the menstrual cycle.

PMS includes a variety of symptoms and it is estimated that as many as 75% of women experience one or more of these symptoms each month. These symptoms may include

• Breast pain
• Melancholy
• anxiety
• headache
• tired
• Emotionally unstable and restless
• Bloating
• Food addicted

Although women with menstruation are prone to PMS, the symptoms of PMS are most common in women in their 20s and 30s. For most women, these symptoms may only cause mild to moderate discomfort or trouble, but in some cases, PMS may be more severe. This is called Premenstrual Discomfort (PMDD).

What caused PMS?

PMS may be the body's response to changes in the hormone levels associated with the menstrual cycle, but no one knows the real reason. Another view is that chemical changes in the brain may be related to PMS, and may also affect the diet (especially salty and caffeinated beverages).

How do I know if I have a PMS?

There are many ways to diagnose PMS, but there is no clear test method. There may be other symptoms similar to those of PMS, so check with your doctor if you are worried about it.

To help diagnose PMS, it is essential that you record the physiologically and psychologically manifested PMS symptoms and the date of the menstrual cycle in 3 or 4 months. It is also helpful to record your daily feeling. After 3 to 4 months, you can probably determine the pattern of symptoms. Although the pattern changes during each menstrual cycle, women with PMS tend to notice that their symptoms stop quickly when the menstrual period really begins. Another model that can help doctors diagnose PMS is whether or not you have a week-long absence of any symptoms during the menstrual cycle.

What can I do to relieve the symptoms?

There are many ways to alleviate the symptoms of PMS, but it may take some attempts to find the one that works best for you.

The most straightforward way to prove it is to make sure to drink more water and ensure a balanced diet. It is best to eat more fresh fruits and vegetables, eat less salt, sugar and processed foods. Many women find that avoiding the intake of caffeine (common in tea, coffee and cola) and alcohol in the presence of PMS may alleviate some of the symptoms. In addition, vitamin B6 and evening primrose oil supplements are recommended as a possible method of alleviating the symptoms of PMS.

Regular exercise can also help, mainly because exercise reduces stress and tension and regulates your mood. If you have a PMS, you may find that walking, swimming or running reduce premenstrual discomfort and try to exercise three times a week for 30 minutes.

If these simple lifestyle changes can not help you control PMS, you should seek more advice from your doctor.

Asthma triggers, control and treatment

A mahogany desk at Mingzhen's home, because of its age, had loose four-legged tables and drawers, and the surface was mottled to look bad. Mingzhen invited carpenter master to the home renovation, before and after a total of four or five days. The master on the desk varnish that day, Mingzhen's little nephew to play at home, the results did not take long, the little guy felt breathless, breathing wheeze breath, Mingzhen scared to quickly take him to the hospital, to the Hospital, little guy's breathing has been a lot of calm. The doctor asks what kind of special stimulating smell in the home, Mingzhen only thinks that the carpenter master's paint makes the little guy's asthma attack, but fortunately leaves the dangerous scene immediately, otherwise does not know what happens. 
In fact, asthma is the case, if you usually pay attention to stay away from the induced environment, improve the prevention awareness, once the attack immediately take effective measures, then the asthma is under your control. Next, let us know about asthma in the incentive, control and treatment of knowledge.

Morbid condition

The pathogenesis of asthma is mainly due to bronchial inflammation, but this inflammation is different from the general bronchial inflammation, the general bronchitis is due to infection with bacteria and viruses, and the pathogenesis of asthma inflammation is very complicated, modern medicine failed to complete Know. Such as tobacco, pets, air pollution, dust, hair, pollen, cold, colds, bronchitis, strenuous exercise, stress, cold winds, climate change, work environment or drugs such as Asprin, etc., when you are exposed to some inducing environment , These triggers stimulate your bronchi and cause bronchial inflammation, and then the tracheal swelling, muscle contraction around the tracheal wall to further narrow the airway, making it difficult for the patient's inhaled air to pass through the bronchi, plus inflammation that increases tracheal mucus and is more severe Block the bronchial circulation. 
Asthma attacks, all the patient's symptoms, such as asthma, cough, chest tightness or shortness of breath, are due to bronchial inflammation and contractions caused by airway stenosis, effective asthma treatment must both inflammation and contraction of the two pathogenesis, in order to timely and effective Relieve symptoms. 
In the United States, about 15 million people have asthma, mostly adults, but 5 million of them also have asthma. Asthma and Allergy are closely linked, so if you have a family history of allergies and asthma, your asthma rates are much higher. Although asthma can occur in people of all ages, it usually starts with childhood.

Asthma symptoms

Some warning signs can remind you that asthma is about to break out. However, not everyone has the same symptoms before or during an asthma attack. The following symptoms are common: 
Warning signs / symptoms: • Breathing begins to accelerate; • Breathing; • Coughing; • Chest tightness; The maximum air flow in your lungs drops. Use a hand-held device to measure the peak air exhaled from your lungs. Ask a doctor to help you find your highest personal reading. 
If the symptoms have just started, take steps according to the pre-existing plan to take prompt relief from your doctor to prevent the situation from getting worse. Relax breathing, try to use cough to discharge mucus in the trachea, and then spit mucus in the paper towel. 
Dangerous signs / immediate need of assistance: ◎ difficult to speak; ◎ lips or nails gray or blue; ◎ heart rate; ◎ rapid relief of ineffective drugs; ◎ maximum lung airflow falls into the red alert that you are currently Your lungs have a 50% reduction in airflow than your usual peak. 
At this point, we should take a series of emergency measures, such as taking drugs for relief, which are usually under the guidance of doctors. If the asthma situation still has no turning point, you should call the doctor in time or go to the emergency room for emergency treatment.

Inducing factors

Avoid predisposing factors, some simple precautions, can help you breathe easier and reduce the attack. 
Away from asthma triggers, some of the stimuli in the environment can induce asthma, but everyone's situation is completely different, so you need to look at what factors can cause your asthma attacks and try to avoid exposing yourself to the most common triggers Environment. 
Tobacco smoke For some asthma patients, if there is tobacco smoke in the home and work environment, the symptoms will be aggravated. Therefore, there are smokers in the family who can try their best to quit smoking after they communicate with each other and are usually away from smoking places. 
Dust mites are microorganisms present in bedding, plush furniture and rugs in home environments. Some people with asthma and rhinitis are particularly sensitive to dust mites. 
Pets Many asthmatic patients develop allergies to animal dander or skin and feathers with pet's spit to induce asthma. Do not allow pets to enter your bedroom or avoid keeping pets in your home. 
Cockroaches Cockroaches are also an important factor in inducing asthma, so keep your home clean and avoid being invaded by cockroaches. 
Indoor Molds If the bedroom is well ventilated and bleach is often used to remove molds from furniture surfaces, do not forget that mold is also a contributing cause of some asthma attacks. 
Pollen If you are allergic to pollens and outdoor molds, tell your doctor that your doctor will develop the appropriate anti-allergy treatment for you. 
Activity / Exercise If you are asthmatic due to exercise and remember to take your prescription medication, your doctor will tell you how to take asthma medication before exercising. 
Other triggers 
◎ Some medications such as aspirin and beta-blockers; 
◎ Sulfites present in foods, such as dried fruit and some beverages like wine; 
◎ Some Chemical or dusty work environment, may irritate your bronchus, or cause allergic reactions; 
◎ infection, infection is an important incentive for asthma, so remember to inject flu, pneumonia vaccine each year, can be effective for people of any age Preventive effect.

Take the initiative to take action

Think about it, is that asthma control you, or are you going to control asthma? Have you carefully observed your condition and documented and even documented the triggers and symptoms of asthma attacks, constantly reminding yourself to develop a lifestyle that avoids the onset of asthma by exposure to triggers or special activities. 
When your asthma is actively controlled by you, your life is as normal as: 
◎ no asthma symptoms at all or most of the time; 
◎ physical activity without any asthma symptoms; 
◎ no delay in school or work due to asthma attacks; 
◎ because there is no asthma symptoms, so sleep at night undisturbed. 
If you inhaled rapid-acting medications twice a week using an inhaler to relieve asthma symptoms (except during or after exercise), your asthma control is not good. 

What is an Asthma Attack And What happens during an asthma attack

Asthma is a chronic disease that commonly attacks the airways of the lungs. In this condition the airways of an asthma patient become narrow, swell and produce extra mucus, thereby making breathing difficult. Asthma attacks can be mild, moderate or severe. Common asthma symptoms include coughing, wheezing, shortness of breath, and tightness in the chest. Asthma can occur at any age, although it most often begins early in life. Young children frequently infected by asthma. sunderlal jain hospital tell you some tips for be aware from Asthma.

Asthma is Incurable -

Asthma is an incurable illness. However, with good treatment and management there is no reason why a person with asthma cannot live a normal and active life. Asthma people are live our life simply with some of extra care and awareness.

What is an Asthma Attack?

An asthma episode, or an asthma attack, is when symptoms are worse than usual. They can come on suddenly and can be mild, moderate or severe.

What happens during an asthma attack?

1,The muscles around your airways tighten up, narrowing the airway.

2,Inflammation of the airways increases, further narrowing the airway.

3.Less air is able to flow through the airway.

Symptoms Signs of asthma include:

• Chest tightness or pain
• Trouble in sleeping, which is caused by shortness of breath
• Whistling sound while exhaling

Asthma can be controlled

There is no cure of asthma. Most people with asthma can minimize their symptoms with some awareness and take a treatment at right time. prevent asthma flare-ups, and improve our diseases or live our life happily. So take a right treatment and care yourself. The right medicine for controlling an asthma attack depends on the patient’s age, severity of the problem, and medical history. Different age people are caused with different types of asthma.

3 Ways To Control Your Asthma Without Using Your Inhaler

Ginger - The ginger compounds used to treat airway smooth muscle and it is best for asthma. Patient take a clearly breath.

Yoga - The deep breathing was best solution for asthma patient. In the morning patient give some time for yoga it will help in asthma.

Butterbur - Butterbur herb use the leaf, root, and bulb to make medicine. This herb has been used for years to treat asthmatics in Asia.

Major Reasons of Heart Attack

The Heart is an important part of our body. The whole body structure depends on the functioning of heart. Circulatory system and heart are combined to perform the function of blood pumping for circulating blood to other parts of the body. The body stops functioning if the heart fails to perform its functions. Therefore, it is necessary to have the knowledge of reasons of heart attack so as to avoid the danger of heart failure. 

The reasons for heart attack are explained in the following manner:

• Age Factor

An Increase in age leads to many diseases. Similarly as the age increases, it affects the functioning of heart. Thus, the probability of heart-attack increases with the increase in age.

• The Disease of Angina

The disease which is caused due to lack of oxygen within the area of the heart is called as angina and this disease boost up the risk of heart-attack.

• Cholesterol

If we want our body should work in a normal way then for such a case cholesterol is a substance which is very indispensable. Increase in cholesterol level attacks the heart definitely.

• Diabetes

Diabetes is a disease which cannot be cured, but it can be controlled. If this disease is not controlled then it gives birth to disruption of heart.

• Food in Large Quantity

If the person eats food in excess that is beyond the limit then there comes the danger of attack cause to heart.

• Hereditary

The disease of the heart-assault develops in an individual by hereditary. If the person possesses the disease of the heart-assault then his children are much more prone to this disease.

• Surgery

People who go through with surgery of heart are in the danger of getting heart-assail.

• Hypertension

Hypertension is a common phenomenon caused due to tension, high work burden and stress and it lead heart-assail.

• Obesity

Obesity is the mother of many diseases. If a person is obese to a higher level then he or she comes under the risk of heart-molestation.

• Activeness

If the person is active then he or she is away from many diseases. Thus, if a person is inactive then he possesses the hazard of heart-molestation.

• Smoking

Smoking is hazardous to our health. The lungs of the person who smoke get destroyed and it is also the cause of heart failure.

• Aids

A Person who develops the virus of HIV in his or her body is very close to disease of the heart-attack.

Treatment

Heart-attack can be treated by having aspirin, nitroglycerin, oxygen therapy, clot busters and percutaneous coronary intervention (nonsurgical process). But these should be used under proper guidance of specialists. One can prefer Saroj Hospital as it is well known hospital for heart care.

Hence, the most common and most dangerous disease in today’s world is heart-attack. This can be controlled only by our awareness and cooperation. If a proper care is taken then it is not a big disease, but if we are careless then it is a way towards death.

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